Table 3.

Summary of circRNAs regulating pathophysiology of AD

circRNAs	Sample type	Cell	Regulation	Target	Function	Potential diagnostic biomarker	Ref.
circMARK3	AAAD ascending aortic specimens	VSMC	Increased	miR‐1273	Promote inflammatory	Yes	47
circRNA‐101238	Type A TAD aortic specimens	VSMC	Increased	miR‐320a	Increase apoptosis	Yes	119
circRNA‐104634		VSMC	Increased	miR‐145‐3p	Promote phenotype switching	Yes
circRNA‐104349		VSMC	Increased	miR‐26a‐3p	Increase apoptosis	Yes
circRNA‐102683		VSMC	Decreased	miR‐29b‐1‐5p	Promote apoptosis/ECM degradation	Yes
circRNA‐104033		VSMC	Decreased	miR‐195‐3p	Stimulate collagen remodelling	Yes

Abbreviations: AAAD, Stanford type A aortic dissection; ECM, extracellular matrix; TAD, thoracic aortic dissection; VSMC, vascular smooth muscle cell.