Table 1.
The function and application of exosomal lncRNAs in cancer
| LncRNA | Type of cancer | Donor cell/recipient cell | Biological function | Clinical application | Reference |
|---|---|---|---|---|---|
| lncARSR | Renal cancer | Drug‐resistant cells/drug‐sensitive cells | Promote sunitinib resistance | Therapeutic target | 24 |
| LNMAT2 | Bladder cancer | Cancer cells/HLECs | Promote lymphatic metastasis | Therapeutic target | 25 |
| MALAT1 | Colorectal cancer | Metastatic cancer cells/primary cancer cells | Promote metastasis | Therapeutic target | 67 |
| RPPH1 | Colorectal cancer | Cancer cells/macrophage M2 | Promote metastasis | Therapeutic and diagnostic target | 68 |
| GAS5 | Lung Cancer | Cancer cells/HUVECs | Promotes angiogenesis | Therapeutic target | 82 |
| AFAP1‐AS1 | Breast cancer | Drug‐resistant cells/drug‐sensitive cells | Promote trastuzumab resistance | Therapeutic target | 75 |
| SNHG14 | Breast cancer | Drug‐resistant cells/drug‐sensitive cells | Promote trastuzumab resistance | Therapeutic target | 76 |
| LINC00461 | Multiple myeloma cell | Mesenchymal stromal cells/multiple myeloma cells | Promote proliferation and suppress apoptosis | Therapeutic target | 63 |
| PART1 | ESCC | Drug‐resistant cells/drug‐sensitive cells | Promote gefitinib resistance | Therapeutic target | 73 |
| PCAT1 | ESCC | Cancer cells/immortalized normal oesophageal epithelial cells | Promote proliferation | Biomarker | 64 |
| TIRY | Oral squamous cell carcinoma | Cancer‐associated fibroblast/cancer cells | Promote metastasis | Therapeutic target | 70 |
| SOX2OT | Pancreatic ductal adenocarcinoma | Cancer cells/cancer cells | Promote metastasis | Biomarker for prognosis | 66 |
| UCF1 | NSCLC | Cancer cells/cancer cells | Promote proliferation, migration and invasion | Biomarker for diagnosis | 60 |
| UCA1 | NSCLC | Drug‐resistant cells/drug‐sensitive cells | Promote gefitinib resistance | Therapeutic target | 71 |
| H19 | NSCLC | Drug‐resistant cells/drug‐sensitive cells | Promote gefitinib resistance | Therapeutic target | 72 |
| HOTTIP | Gastric cancer | Drug‐resistant cells/drug‐sensitive cells | Promote cisplatin resistance | Therapeutic target | 78 |
| TUG1 | Cervical cancer | Cancer cells/HUVECs | Promote angiogenesis | Target for early diagnosis | 81 |
| CCAT2 | Glioma | Cancer cells/HUVECs | Promote angiogenesis | Therapeutic target | 83 |
| LINC‐POU3F3 | Glioma | Cancer cells/human brain microvascular endothelial cells | Promote angiogenesis | Therapeutic target | 84 |