FIGURE 3.

The effect of PIO on pathological kidney morphology and cell apoptosis in cisplatin nephrotoxicity. A, HE staining and TUNEL were used to observe pathological kidney morphology (200× magnification) and cell apoptosis (400× magnification) in cisplatin nephrotoxicity. B, Semi‐quantitative assessment of the pathological injury morphology in the kidneys. C, Semi‐quantitative assessment of cell apoptosis. Bars represent the mean ± SEM (n = 10). ^*** P < .001, (Cis vs Con); ^# P < .05 (PIO vs Cis); ^{^} P < .05 (EX vs PIO). Cis, cisplatin; Con, control; PIO, Pioglitazone; EX, EX527