Table 2.

Bone biology data. Observed concentration (Obs conc.) values of undifferentiated (undiff) and osteogenic differentiated (OG) MSPCs were listed. Significant differences between the undifferentiated and differentiated groups are displayed with an asterix (*), the differences between the original CoCrMo surface and the surface modifications (SM) are represented by rhombus (#) (mean ± SD; n = 5, measured in duplicates).

	pg/mL
Gene	CoCrMo	Polished	Porous	TiN	cpTi
OC undiff	1200 ± 419	805 ± 218	467 ± 69	1195 ± 306	999 ± 379
OC OG	2003 ± 591	3158 ± 775 *	1727 ± 447 *	3117 ± 699 *	354 ± 184 *
SM undiff.		n.s.	#	n.s.	n.s.
SM OG		n.s.	n.s.	n.s.	##
OPG undiff	4934 ± 879	4279 ± 593	6221 ± 840	4224 ± 639	7674 ± 710
OPG OG	4176 ± 1462	4740 ± 1178	5985 ± 2565	4583 ± 1043	6315 ± 2307
SM undiff.		n.s.	n.s	n.s.	##
SM OG		n.s.	n.s	n.s.	n.s.
SOST undiff	58.8 ± 21	65.1 ± 8	73.6 ± 11.8	56.2 ± 10.5	35.0 ± 7.9
SOST OG	115 ± 7.9 *	112.5 ± 8.6 ***	117.1 ± 13.8 *	107.3 ± 11.3 **	116.7 ± 17.6 **
SM undiff.		n.s.	#	n.s.	n.s.
SM OG		n.s.	n.s.	n.s.	n.s.
IL6 undiff	1957 ± 426	2114 ± 575	5208 ± 1230	2099 ± 324	4857 ± 1556
IL6 OG	187 ± 128 ***	262 ± 57 *	218 ± 76 *	295 ± 91 **	435 ± 296 *
SM undiff.		n.s.	#	n.s.	#
SM OG		n.s.	n.s.	n.s.	n.s.
Leptin undiff	27.3 ± 4.5	17.7 ± 4.6	267 ± 107	33 ± 12.3	313 ± 175
Leptin OG	3642 ± 1877 ***	1478 ± 405 **	2230 ± 811 **	2498 ± 549 ***	14911 ± 4053 ***
SM undiff.		#	#	n.s.	##
SM OG		n.s.	n.s.	n.s.	##
DKK undiff	371 ± 196	311 ± 79	1978 ± 737	266 ± 106	659 ± 232
DKK OG	4410 ± 468 ***	4179 ± 449 ***	3816 ± 1482	4350 ± 641 ***	5557 ± 1266 **
SM undiff.		n.s.	#	n.s.	n.s.
SM OG		n.s.	n.s.	n.s.	n.s.

***: p < 0.001; **,##: p < 0.01; *,#: p < 0.05; n.s.: not significant.