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. 2020 Oct 8;13(19):4454. doi: 10.3390/ma13194454

Table 4.

Antimicrobial effects of NCA on selected microbial strains.

Compound Relation Value [mmol/L] Standard Microorganism Strain Source
BA >= 0.52 MIC Staphylococcus aureus [144]
> 1.05 MIC Staphylococcus aureus [144]
= 6.55 MIC Saccharomyces cerevisiae [145]
= 6.55 MIC Saccharomyces cerevisiae [145]
= 6.55 MIC Saccharomyces cerevisiae [145]
= 6.55 MIC Phellinus tremulae [146]
> 13.10 MIC Saccharomyces cerevisiae [145]
> 13.10 MIC Saccharomyces cerevisiae [145]
= 0.33 MIC Mycobacterium tuberculosis [147]
= 5.00 MIC Cochliobolus lunatus [148]
= 5.00 MIC Lasiodiplodia theobromae [146]
= 5.00 MIC Neofusicoccum ribis [146]
= 5.00 MIC Diplodia seriata [146]
= 5.00 MIC Botryosphaeria dothidea [146]
CinA = 3.37 MIC Aspergillus parasiticus [149]
> 0.86 MIC Streptococcus pyogenes [150]
> 0.86 MIC Staphylococcus aureus [150]
= 0.27 MIC Mycobacterium tuberculosis H37Rv [151]
= 1.68 MIC Aspergillus niger [149]
= 3.37 MIC Staphylococcus aureus [149]
> 0.86 MIC Staphylococcus epidermidis [150]
= 6.75 MIC Klebsiella pneumoniae [149]
= 6.75 MIC Bacillus subtilis [149]
> 0.86 MIC Pseudomonas aeruginosa [150]
> 0.86 MIC Staphylococcus aureus [150]
= 0.42 MIC Trichophyton rubrum [149]
> 0.86 MIC Escherichia coli [150]
= 0.84 MIC Issatchenkia orientalis [149]
= 6.75 MIC Burkholderia cepacia [149]
= 6.75 MIC Micrococcus luteus [149]
= 6.75 MIC Enterobacter cloacae [149]
> 0.86 MIC Bacillus subtilis [150]
> 0.60 MIC Mycobacterium smegmatis str. MC2 155 [151]
= 13.50 MIC Pseudomonas aeruginosa [149]
p-CA > 0.60 MIC Mycobacterium smegmatis str. MC2 155 [151]
= 5.00 MIC Diplodia seriata [146]
> 305 MIC Bacillus subtilis [152]
= 0.24 MIC Mycobacterium tuberculosis H37Rv [151]
= 5.00 MIC Neofusicoccum ribis [146]
> 305 MIC Candida albicans [152]
> 305 MIC Staphylococcus aureus [152]
= 5.00 MIC Botryosphaeria dothidea [146]
> 305 MIC Pseudomonas fluorescens [152]
= 0.37 MIC Mycobacterium bovis BCG [151]
CFA > 0.28 MIC Bacillus subtilis [152]
> 0.28 MIC Staphylococcus aureus [152]
= 0.71 MIC50 Candida albicans [153]
= 0.69 MIC Streptococcus pyogenes [154]
= 0.69 MIC Staphylococcus aureus [154]
> 0.30 IC50 Saccharomyces cerevisiae [155]
> 0.28 MIC Pseudomonas fluorescens [152]
> 0.35 IC50 Agaricus bisporus [156]
= 1.47 MIC50 Candida albicans [153]
= 0.28 MIC50 Candida albicans [153]
> 0.28 MIC Candida albicans [152]
= 0.71 MIC50 Candida albicans [153]
RA > 5556 MIC Aspergillus niger [157]
= 11111 MIC Aspergillus niger [158]
= 333 MBC Bacillus subtilis subsp. spizizenii [157]
= 11111 MBC Bacillus subtilis subsp. spizizenii [158]
= 11111 MIC Bacillus subtilis subsp. spizizenii [158]
> 5556 MIC Candida albicans [157]
= 5556 MIC Candida albicans [158]
> 5556 MIC Escherichia coli [157]
= 333 MBC Escherichia coli [157]
> 5556 MIC Pseudomonas aeruginosa [157]
= 333 MBC Pseudomonas aeruginosa [157]
= 11111 MBC Pseudomonas aeruginosa [158]
= 5556 MIC Pseudomonas aeruginosa [158]
= 333 MIC Staphylococcus aureus [157]
= 333 MBC Staphylococcus aureus [157]
= 333 MBC Staphylococcus aureus [158]
= 333 MIC Staphylococcus aureus [158]
= 333 MIC Staphylococcus epidermidis [157]
= 333 MBC Staphylococcus epidermidis [157]
= 2778 MBC Staphylococcus epidermidis [158]
= 333 MIC Staphylococcus epidermidis [158]
D-ChA = 0.0039 Ki Clostridium botulinum * [159]
= 0.0067 Ki Clostridium botulinum # [159]
= 0.0016 Ki Clostridium botulinum ** [159]
= 0.0014 Ki Clostridium botulinum ## [159]
L-ChA = 0.0158 Potency Bacillus anthracis str. A2012 [160]

MIC—minimum inhibitory concentration, MIC50—minimum inhibitory concentration required to inhibit the growth of 50% of microorganisms, Ki—inhibitory constant, MBC—minimum bactericidal concentration, IC50—the half maximal inhibitory concentration. Uncompetitive inhibition of Clostridium botulinum: * full length BoNT/A light chain (1-448) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis, ** truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis, Competitive inhibition of Clostridium botulinum: # truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis, ## full length BoNT/A light chain (1-448) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis.