We recommend irradiation in patients with aggressive disease or resistance (or intolerance) to drugs.

We suggest considering irradiation in patients willing to have a definitive cure regardless of sensitivity to drugs.

We recommend that the technique of irradiation should be selected according to the size of residual adenoma, and proximity to the optic pathways.

We recommend that irradiation, regardless of technique, should be administered by a skilled operator.

We recommend a yearly follow-up to evaluate the efficacy and safety of previous irradiation.