Table 3.
Overview of the immunogenicity and HLA-A2 binding affinity of candidate peptides predicted by the POTN model.
| Peptide | Prediction score | Binding | Immunogenicity* |
|---|---|---|---|
| KLSSIIPSA | 1.1299 | ++ | 1/5 |
| FLAKLNNTV | 1.1257 | + | \ |
| FLSKLSSII | 1.1157 | - | \ |
| VLSAVTPEL | 1.1020 | + | \ |
| VLSNVLSGL | 1.1010 | + | \ |
| SIDDLSFYV | 1.0988 | ++ | 4/5 |
| ILDRANQSV | 1.0906 | ++ | 3/5 |
| YLATADMPA | 1.0898 | ++ | 3/5 |
| ALDEKVAEL | 1.0847 | ++ | 4/5 |
| ALSTVLPGL | 1.0832 | ++ | 2/5 |
| TLDEKVAEL | 1.0777 | ++ | 5/5 |
| TLDQVLDEV | 1.0680 | ++ | 5/5 |
| AMASASPSV | 1.0663 | ++ | 3/5 |
| VLSTAPPQL | 1.0654 | ++ | 4/5 |
| KVADLIHFL | 1.0653 | + | \ |
| KVAELVHFL | 1.0627 | + | \ |
| LMDVQIPTA | 1.0546 | ++ | 5/5 |
| ALSVMGVYV | 1.0541 | + | \ |
| FLAMLKNTV | 1.0498 | + | \ |
| KVAKLVHFL | 1.0493 | + | \ |
| KMAGELIKI | 1.0386 | ++ | 4/5 |
| FIDKLVESV | 1.0359 | ++ | 5/5 |
Prediction scores were ranked and retained with four decimal digitals. -, FI < 0.5; +, FI ≥ 0.5 to < 1.5; ++, FI ≥ 1.5; \, no experimental data. *The response ratio of each peptide in five donors detected by the percentages of IFN-γ+-secreting CD8+ T cells.