Table 2.
Hazard ratios and 95% CIs of different numbers of total alcohol drinks /day for gastric adenocarcinoma in the NIH-AARP Diet and Health Study Cohort (1995-2011)
| Groups | Variable | Gastric cardia adenocarcinoma | Gastric non-cardia adenocarcinoma | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total alcohol (drinks/ day) | Total alcohol (drinks/ day) | ||||||||||
| never | >0-1 | >1-3 | >3 | Ptrend | never | >0-1 | >1-3 | >3 | Ptrend | ||
| All participants1 | No. of cases | 155 | 312 | 113 | 82 | 202 | 344 | 116 | 51 | ||
| HR (95%CI) | 1.00 | 0.86(0.70-1.05) | 0.91(0.70-1.17) | 1.06(0.80-1.42) | 0.8 | 1.00 | 0.81(0.67-0.97) | 0.96(0.76-1.23) | 0.73(0.53-1.01) | 0.2 | |
| Exclude poor health2 | No. of cases | 111 | 275 | 98 | 78 | 160 | 313 | 106 | 45 | ||
| HR (95%CI) | 1.00 | 0.96(0.76-1.20) | 0.94(0.71-1.26) | 1.25(0.92-1.71) | 0.3 | 1.00 | 0.85(0.70-1.04) | 1.00(0.77-1.29) | 0.75(0.53-1.06) | 0.3 | |
| Exclude first 2-year cases3 | No. of cases | 134 | 271 | 97 | 72 | 170 | 296 | 94 | 46 | ||
| HR (95%CI) | 1.00 | 0.86(0.69-1.07) | 0.89(0.68-1.18) | 1.07(0.79-1.46) | 0.8 | 1.00 | 0.83(0.68-1.01) | 0.94(0.72-1.22) | 0.80(0.57-1.13) | 0.3 | |
| Drinkers only4 | No. of cases | 312 | 113 | 82 | 344 | 116 | 51 | ||||
| HR (95%CI) | - | 1.00 | 1.03 (0.82-1.29) | 1.25 (0.96-1.63) | 0.1 | - | 1.00 | 1.19 (0.96-1.49) | 0.88 (0.65-1.20) | 1.0 | |
| Stratification Model5 | |||||||||||
| Sex | |||||||||||
| Male | No. of cases | 128 | 280 | 96 | 78 | 124 | 242 | 98 | 47 | ||
| HR (95%CI) | 1.00 | 0.90(0.72-1.12) | 0.84(0.64-1.11) | 1.07(0.79-1.44) | 1.0 | 1.00 | 0.84(0.67-1.06) | 1.01(0.77-1.33) | 0.75(0.53-1.06) | 0.3 | |
| Female | No. of cases | 27 | 32 | 17 | 4 | 78 | 102 | 18 | 4 | ||
| HR (95%CI) | 1.00 | 0.60(0.34-1.04) | 1.63(0.83-3.20) | 1.30(0.43-3.88) | 0.3 | 1.00 | 0.76(0.56-1.05) | 0.88(0.51-1.50) | 0.66(0.24-1.83) | 0.2 | |
| Education level | |||||||||||
| Less than or high school graduate6 | No. of cases | 77 | 114 | 33 | 18 | 93 | 141 | 43 | 17 | ||
| HR (95%CI) | 1.00 | 0.83(0.61-1.12) | 0.85(0.55-1.30) | 0.63(0.36-1.10) | 0.1 | 1.00 | 0.92(0.70-1.21) | 1.20(0.83-1.76) | 0.71(0.41-1.20) | 0.6 | |
| Some college | No. of cases | 35 | 67 | 31 | 24 | 41 | 84 | 24 | 15 | ||
| HR (95%CI) | 1.00 | 0.77(0.50-1.17) | 1.08(0.65-1.79) | 1.04(0.58-1.84) | 0.5 | 1.00 | 0.78(0.53-1.15) | 0.77(0.45-1.30) | 0.84(0.46-1.56) | 0.5 | |
| College graduate | No. of cases | 43 | 131 | 49 | 40 | 68 | 119 | 49 | 19 | ||
| HR (95%CI) | 1.00 | 1.01(0.71-1.46) | 0.94(0.61-1.45) | 1.60(1.02-2.53) | 0.1 | 1.00 | 0.70(0.51-0.95) | 0.88(0.60-1.31) | 0.69(0.40-1.17) | 0.3 | |
| Smoking status | |||||||||||
| Never smoker | No. of cases | 29 | 57 | 18 | 7 | 82 | 98 | 24 | 6 | ||
| HR (95%CI) | 1.00 | 1.03(0.65-1.63) | 1.36(0.74-2.49) | 1.36(0.58-3.17) | 0.3 | 1.00 | 0.74(0.55-1.00) | 0.91(0.56-1.46) | 0.63(0.27-1.45) | 0.2 | |
| Former smoker | No. of cases | 91 | 190 | 64 | 50 | 82 | 172 | 75 | 33 | ||
| HR (95%CI) | 1.00 | 0.85(0.66-1.09) | 0.73(0.53-1.02) | 1.03(0.72-1.47) | 0.6 | 1.00 | 0.90(0.69-1.18) | 1.12(0.81-1.55) | 0.85(0.56-1.29) | 0.9 | |
| Current smoker | No. of cases | 26 | 42 | 25 | 19 | 28 | 49 | 15 | 12 | ||
| HR (95%CI) | 1.00 | 0.71(0.43-1.16) | 1.24(0.70-2.18) | 0.97(0.53-1.79) | 0.5 | 1.00 | 0.78(0.49-1.25) | 0.72(0.38-1.36) | 0.60(0.30-1.21) | 0.1 | |
HRs come from Cox models adjusted for age, sex, ethnic group, health status, educational level, BMI, smoking status, self-reported diabetes, and healthy eating index 2010.
sensitivity analysis, excluding participants self-reported as poor/fair health status.
sensitivity analysis, excluding gastric adenocarcinomas identified in the first 2 years.
sensitivity analysis, excluding non-drinkers.
HRs come from Cox models adjusted for age, sex, ethnic group, health status, educational level, BMI, smoking status, self-reported diabetes, and healthy eating index 2010, except for the stratification variable in each subgroup analysis.
including less than high school, completed high school, and some post-high school training.