Table 1.
Binding Kinetics of ZIKV E–GAG Interactions from SPR Binding Assays
| ka (M−1 s−1) | kd (s−1) |
KD (nM) |
|
|---|---|---|---|
| porcine intestinal HP | 9.67 × 103a (±135) | 4.28 × 10−3 ± 4.6 × 10−5 | 443 |
| human placental HS | 2.32 × 103 (±123) | 2.95 × 10−3 ± 4.9 × 10−5 | 894 |
| human placental CS | 4.10 × 103 (±92) | 2.70 × 10−3 ± 1.5 × 10−4 | 658 |
| porcine brain HS | 2.07 × 103 (±42) | 2.02 × 10−3 ± 8.2 × 10−5 | 977 |
| porcine brain CS | 1.86 × 103 (±49) | 2.45 × 10−3 ± 1.4 × 10−4 | 1310 |
a
The values in parentheses are the standard deviations (SDs) from global fitting of five injections.