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. 2020 Sep 11;24(20):12141–12153. doi: 10.1111/jcmm.15859

FIGURE 7.

FIGURE 7

Effects of silencing Nrf2 on antioxidation and apoptosis‐related proteins in cells with doxorubicin exposure. A, Western blots and relative levels of HO‐1 in H9C2 cardiomyoblasts transfected with control siRNA or Nrf2 siRNA and subjected to doxorubicin injury in the absence (V, vehicle) or presence of 3 μM acacetin (Aca). B, Western blots and relative levels of SOD1 in H9C2 cardiomyoblasts with the same treatment as in A. C, Western blots and relative levels of SOD2 in H9C2 cardiomyoblasts with the same treatment as in A. D, Western blots and relative levels of Bcl‐2 in H9C2 cardiomyoblasts with the same treatment as in A. E, Western blots and relative levels of Bax in H9C2 cardiomyoblasts with the same treatment as in A. F, Western blots and relative levels of cleaved caspase‐3 in H9C2 cardiomyoblasts with the same treatment as in A (n = 5 individual experiments, * P < 0.05, ** P < 0.01 vs vehicle of control siRNA; ## P < 0.01 vs control siRNA with acacetin)