TABLE 3.
Summarized diagnostic factors of the individual miRNA and combined miRNA panels
| Value (mean, SD) | Fold change (eGFR ≥ 90/eGFR < 60) | Cut‐off value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | ||
|---|---|---|---|---|---|---|---|
| eGFR ≥ 90 | eGFR < 60 | ||||||
| log2(miR‐21/miR‐16) | −1.98 (0.78) | −1.21 (0.75) | 1.64 | >−1.85 | 0.78 (0.65‐0.91) | 88.46 | 66.67 |
| log2(miR‐210/miR‐16) | −6.52 (0.52) | −5.93 (0.83) | 1.10 | >−5.96 | 0.74 (0.60‐0.88) | 55.56 | 92.31 |
| log2(miR‐4639/miR‐16) | −5.03 (1.87) | −2.89 (1.48) | 1.74 | >−3.77 | 0.81 (0.69‐0.93) | 84.62 | 76.92 |
| miR‐21 + 210 (score) | 0.35 (0.22) | 0.65 (0.24) | 0.54 | >0.46 | 0.83 (0.71‐0.95) | 88.46 | 73.08 |
| miR‐21 + 4639 (score) | 0.28 (0.27) | 0.72 (0.25) | 0.39 | >0.42 | 0.88 (0.79‐0.97) | 88.46 | 73.08 |
| miR‐210 + 4639 (score) | 0.33 (0.28) | 0.67 (0.21) | 0.49 | >0.51 | 0.82 (0.71‐0.93) | 80.77 | 73.08 |
| miR‐21 + 210 + 4639 (score) | 0.28 (0.27) | 0.72 (0.25) | 0.39 | >0.43 | 0.89 (0.80‐0.97) | 88.46 | 73.08 |
Abbreviations: AUC, area under the curve; CI, confidence interval; eGFR, estimated glomerular filtration rate (mL/min/1.73 m2); ROC curve, receiver operating characteristic curve.