Figure 2.

Somatic mutations are enriched in miRNA regions but not random regions. A, Mean mutation rate in ICGC (International Cancer Genome Consortium) database of miRNA (left panel) and random regions (right panel): Mann‐Whitney U Test, P = 1.63e−9; B, Mean mutation rate in TCGA (The Cancer Genome Atlas) database of miRNA (left panel) and random regions (right panel): Mann‐Whitney U Test, P < 2.2e−16. ‘TSS’ indicates the transcriptional starting sites while ‘TES’ indicates the transcriptional end sites. C, Waterfall plots for highly mutated CRC genes (more than 10% mutation rate) based on 405 samples. Top 10 key CRC genes include APC, TP53, KRAS, PIK3CA, FAT4, FBXW7, CSMD3, BRAF, LRP1B and SMAD4. D‐G, Mutation distribution of (D): top 10 key CRC genes in miRNA regions, (E): excluding top 10 key CRC genes in miRNA regions, (F): top 10 key CRC genes in CBS regions, (G): excluding top 10 key CRC genes in CBS regions