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. 2020 Sep 11;24(20):11755–11767. doi: 10.1111/jcmm.15788

Figure 6.

Figure 6

MiR‐455‐5p rescued effect on the proliferation and invasion of lncRNA HOXA‐AS3 overexpression glioblastoma multiforme (GBM) cells. A, MTT experiments suggested that MiR‐455‐5p rescued the effect of lncRNA HOXA‐AS3 on migration of LN229 cell and U251 cell (**P < .01, ***P < .001). B, Transwell assay was conducted to evaluate the effect of miR‐455‐5p on the proliferation of lncRNA HOXA‐AS3 overexpressed LN229 cells and U251 cells (**P < .01, ***P < .001). C, Colony formation assay showed that miR‐455‐5p inhibited the cell proliferative capacity rescued by lncRNA HOXA‐AS3 (**P < .01). D, Representative images of tumour viewed by IVIS after control group, shRNA lncRNA HOXA‐AS3 group and miR‐455‐5p inhibitor group inoculation. E, Western blot analysis showed protein expression of E‐cadherin, N‐cadherin, vimentin and USP3 in orthotopic xenograft tumour lncRNA HOXA‐AS3 knock‐down group and NC control group (*P < .05,**P < .01 and ***P < .001)