TABLE 1.
Correlation between AKR1B10P1 transcript and clinicopathologic features in 87 HCC specimens
| Clinicopathologic parameters | AKR1B10P1 expression | P* | |
|---|---|---|---|
| Low (n = 11) | High (n = 76) | ||
| Age (years) | |||
| ≤50 | 8 | 38 | 0.205 |
| ＞50 | 3 | 38 | |
| Gender | |||
| Male | 7 | 41 | 0.748 |
| Female | 4 | 35 | |
| Diameter (cm) | |||
| ≤5 | 9 | 34 | 0.025 |
| ＞5 | 2 | 43 | |
| TNM stage | |||
| I～II | 8 | 28 | 0.045 |
| III～IV | 3 | 48 | |
| Tumour encapsulation | |||
| Absent | 6 | 30 | 0.514 |
| Present | 5 | 46 | |
| Tumour microsatellite formation | |||
| Absent | 9 | 28 | 0.007 |
| Present | 2 | 48 | |
| Venous invasion | |||
| No | 6 | 22 | 0.164 |
| Yes | 5 | 54 | |
| HBsAg | |||
| Negative | 3 | 8 | 0.141 |
| Positive | 8 | 68 | |
| AFP(ng/ml) | |||
| ≤400 | 10 | 10 | ＜0.01 |
| ＞400 | 1 | 66 | |
| Cirrhosis | |||
| Absent | 5 | 5 | 0.023 |
| Present | 6 | 71 | |
AKR1B10P1 transcript level associated with clinicopathologic features in 87 HCC patients, including age, gender, tumour size, tumour stage (AJCC), tumour encapsulation, tumour microsatellite formation, vein invasion, HBsAg status, AFP level and liver cirrhosis. Statistically significance was assessed by Fisher's exact text.