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. 2020 Aug 27;24(20):11729–11741. doi: 10.1111/jcmm.15783

Figure 4.

Figure 4

WISP1 reduces scavenger receptor (CD36 and SR‐A) levels in the arteries of ApoE‐/‐ mice. Western blot analysis of WISP1 (A), CD36 (B) and SR‐A (C). HFD can up‐regulate WISP1 via the Wnt5a/β‐catenin pathway. Western blot analysis of Wnt5a (D), β‐catenin (E) and WISP1 (F) (*P < .05, **P < .01, ***P < .001; data = means ±SD). HFD: high‐fat diet; NC: null lentivirus; IvWISP1: lentivirus WISP1; shWISP1: WISP1‐shRNA; WISP1: WNT1‐inducible signalling pathway protein