Figure 8.

Proposed schematic model (A) Ox‐LDL can depolarize mitochondrial membrane and trigger excessive reactive oxygen species (ROS). ROS can activate Wnt5a/β‐catenin pathway and then up‐regulate expression of WISP1. While ROS inhibition NAC can reduced WISP1 expression under the stimulation of ox‐LDL. (B) WISP1 expressed in the cytosol where it catalyses ubiquitination and subsequent degradation of PPARγ through direct interaction, consequently inhibiting its transcriptional activity. Inhibition of PPARγ can inhibit its downstream CD36. Besides, WISP1 can down‐regulate the expression of SR‐A. CD36 and SR‐A are crucial for lipid deposition