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Receiver operating characteristic curves of serum markers. A: Human epididymis protein 4 (HE4), carcinoma embryonic antigen (CEA), alpha fetal protein (AFP), and carbohydrate antigen 19-9 (CA19-9) for the diagnosis of esophageal squamous cell carcinoma (ESCC); B: Combination of serum markers HE4, CEA, AFP, and CA19-9 for the diagnosis of ESCC. HE4: Human epididymis protein 4; CEA: Carcinoma embryonic antigen; AFP: Alpha fetal protein; CA19-9: Carbohydrate antigen 19-9.
