Protein domain and motif abbreviations are indicated as following: Cys string, cysteine string; α-helix, an amphipathic alpha–helix; RGS, regulator of G-protein signaling domain; DEP, disheveled EGL10-Pleckstrin homology domain; GGL, G protein gamma subunit-like domain; R1&R2, Ras/Rap-binding domain; G, G protein regulator motif; PTB, phosphotyrosine binding domain; PDZ, PSD95/Dlg/Z0-1/2 domain.