Table 2:
Regulation of RGS10 expression
| Cell/Tissue | Stimuli/Disease model | mRNA/Protein | Expression | Reference(s) |
|---|---|---|---|---|
| BMDM cell | FSL-1 100 nM (2&6 h) | mRNA | Decrease | [132] |
| LPS 10 ng/ml (3 h) | mRNA | |||
| LPS 100 ng/ml (48 h) | Protein | Decrease | [101] | |
| Primary microglia cell | LPS 10 ng/ml (6 h) | mRNA | Decrease | [78] |
| LPS 10 ng/ml (24,48&72 h) | Protein | Decrease | [48] | |
| BV2 cell | LPS 10 ng/ml (4–72 h) | mRNA | Decrease | [78] |
| LPS 10 ng/ml (48 h) | Protein | [48] | ||
| TNF-α 10 ng/ml (24,48&72 h) | Protein | |||
| TSA 100,250,500 nM (24 h) | mRNA | Increase | [78] | |
| S1P 10 μM (48 h) | mRNA | |||
| Spinal dorsal horn (L4-L5) tissue | pSNL model of inflammatory neuropathic pain (72 h) | Protein | Decrease | |
| MN9D cell | TNF-α 10 ng/ml (6&24 h) | mRNA/ Protein | Decrease | [99] |
| Phagocytic (MGdNΦ) microglia cell | Injection of apoptotic neurons (dN) into the cortex and hippocampus of WT mice | Protein | Decrease | [133] |
| Chondrocytes | Differentiation (9,12&15 days) | mRNA | Increase | [113] |
| Hippocampus | Acute electroconvulsive seizures ECS (24 h) | mRNA | Decrease | [134] |
| Ventral tegmental | Amphetamine (AMPH) self-administration | mRNA | Decrease | [135] |
| SKOV-3 cell | Cisplatin 100 μM (48 h) | mRNA | Decrease | [124] |
| 5-Aza (3,5,7&9 days) | mRNA | Increase | [49] | |
| A2780-AD cell | TSA 500 nM (48&36 h) | mRNA | Increase | [76] |
| 5-Aza 10 μM&20 μM (3,5&7 days) | mRNA | |||
| Caco-2 cell | Black tea polyphenol (Theaflavins TF-2) 50 μM (4–24 h) | mRNA | Increase | [136] |
| Striatum | Reserpine Acute treatment (30 min) | mRNA | Increase | [137] |
| Daily reserpine (5 days) | Decrease | |||
| Neonatal rat cardiomyocytes | Angiotensin II 50 μmol/L (24&48 h) | protein | Decrease | [108] |
| Human neural progenitor (hNP) | 5-Aza 5 μM (5 days) | mRNA | Increase | [77] |
| Molt-4 cell | CXCL-12 (30&60 min) | protein | Increase | [53] |
| Osteoclast derived BMM | RANKL+M-CSF (10 ng/ml) (30 min-96 h) | mRNA | Increase | [111] |
| protein | ||||
| RAW264.7 cell | RANKL+M-CSF (10 ng/ml) (30 min-96 h) | mRNA | Increase | [47] |
| Paw and spinal cord | Trimethylamine N-oxide (TMAO) (24 h) | Protein | Decrease | [138] |
BMDM, bone marrow derived macrophage; FSL-1, Pam2CGDPKHPKSF, synthetic diacylated lipoprotein; LPS, lipopolysaccharide; MN9D, mesencephalon neuroblastoma cell line; RANKL, receptor activator of nuclear factor-κB-ligand; TNF-α, tumor necrosis factor-alpha; TSA, trichostatin A; 5-Aza, 5-Azacytidine; M-CSF, Macrophage colony-stimulating factor; S1P, sphingosine-1-phosphate; pSNL, partial sciatic nerve ligation.