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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Cell Signal. 2020 Aug 31;75:109765. doi: 10.1016/j.cellsig.2020.109765

Table 3:

RGS10-associated loss of function phenotypes and disease links

Phenotype(s) Proposed disease links Year Reference(s)
Impaired osteoclasts differentiation Osteopetrosis 2007 [47, 111]
Neuroinflammation and neurodegeneration Parkinson’s disease and a possible link to schizophrenia 2008 [48, 94, 96]
Reduced chemotherapy-induced cell death Ovarian cancer chemoresistance 2010 [124, 125]
Hypertrophy following pressure overload Heart failure 2015 [108]
Platelets aggregation and thrombogenesis Aspirin resistance 2016 [119, 121]
Increased body weight with insulin resistance and glucose intolerance Obesity and related metabolic syndromes 2019 [131]