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. 2020 Oct 14;26(38):5822–5835. doi: 10.3748/wjg.v26.i38.5822

Figure 2.

Figure 2

Acetyl-11-keto-β-boswellic acid inhibits the proliferation and induces the apoptosis of gastric cancer cells. A and B: Dose- and time-dependent effects of acetyl-11-keto-β-boswellic acid (AKBA) on BGC823 and SGC7901 cell proliferation; C: Flow cytometry-based annexin V-FITC/PI labeling of apoptotic cells; D: Histogram showing apoptosis rates; E: Expression levels of proliferating cell nuclear antigen (PCNA), Bcl-2, and Bax in BGC823 and SGC7901 cells measured via Western blot analysis after AKBA treatment; F and G: Histograms showing the relative expression levels of PCNA, Bcl-2, and Bax compared with GAPDH in BGC823 and SGC7901 cells. Each data point represents the mean ± SD from three independent experiments. aP < 0.05, bP < 0.01 vs control (0 µM). cP < 0.05, dP < 0.01 vs control (24 h). AKBA: Acetyl-11-keto-β-boswellic acid; PCNA: Proliferating cell nuclear antigen; GAPDH: Glyceraldehyde-phosphate dehydrogenase.