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. 2020 Oct 9;20(6):171. doi: 10.3892/etm.2020.9301

Figure 4.

Figure 4

Activation of endoplasmic reticulum stress restores IL-6 and TNF-α production following HIPK2 knockdown in LPS-stimulated macrophages. ELISA analysis of (A) IL-6 and (B) TNF-α levels in the supernatants with or without TM treatment in PMs following HIPK2 knockdown (n=3). (C) Western blot analysis of p-p65 and p65 levels in PMs treated with or without TM following HIPK2 knockdown. *P<0.05 as indicated. HIPK2, homeodomain-interacting protein kinase 2; LPS, lipopolysaccharides; PMs, peritoneal macrophages; TM, tunicamycin; p-, phosphorylated; si, small interfering RNA; NS, not significant.