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. 2020 Oct 9;20(6):171. doi: 10.3892/etm.2020.9301

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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HIPK2 inhibition suppresses IL-6 and TNF-α production in vitro and in vivo. ELISA analysis of (A) IL-6 and (B) TNF-α levels in the serum of mice treated with or without tBID and LPS stimulation for 6 h (n=3). ELISA analysis of (C) IL-6 and (D) TNF-α levels in the supernatants of bone marrow-derived macrophages treated with or without tBID and challenged with LPS for 6 h (n=6). ELISA analysis of (E) IL-6 and (F) TNF-α levels in the serum of mice treated with or without tBID and TM (three independent repeated experiments). ^*P<0.05 as indicated. HIPK2, homeodomain-interacting protein kinase 2; LPS, liposaccharides; TM, tunicamycin; NS, not significant; tBID (4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)isoindoline-1,3-dione).