Table 4.
Features of genomic alterations in colon polyps
| Genomic alterations | Pathological diagnoses of colon polyps / (N) | |||||
|---|---|---|---|---|---|---|
| AC/ | HYP/ | SA/ | TA/ | TVA/ | VA/ | |
| 32 | 17 | 16 | 80 | 40 | 13 | |
| APC mutation | ||||||
| + Frameshift | 10 | 1 | 0 | 19 | 13 | 5 |
| + Nonsense | 5 | 1 | 2 | 15 | 8 | 1 |
| + Nonsense and Frameshift | 1 | 0 | 0 | 0 | 0 | 0 |
| + Missense and Frameshift | 0 | 0 | 0 | 1 | 1 | 0 |
| + Nonsense and Missense | 0 | 0 | 0 | 2 | 0 | 0 |
| Total | 16 | 2 | 2 | 37 | 22 | 6 |
| KRAS mutation | ||||||
| + Codon 12 | 8 | 2 | 2 | 4 | 13 | 6 |
| + Codon 13 | 2 | 0 | 0 | 3 | 2 | 4 |
| + Both | 1 | 0 | 0 | 0 | 0 | 0 |
| Total | 11 | 2 | 2 | 7 | 15 | 10 |
| 20q13.33 copy number | ||||||
| + Loss | 0 | 0 | 0 | 3 | 1 | 0 |
| + Gain | 20 | 14 | 11 | 52 | 19 | 8 |
| Total | 20 | 14 | 11 | 55 | 20 | 8 |
| MSI status | ||||||
| + MSS | 22 | 12 | 10 | 67 | 29 | 8 |
| + MSI-L | 4 | 1 | 2 | 12 | 6 | 4 |
| + MSI-H | 6 | 4 | 4 | 1 | 5 | 1 |
| Total | 32 | 17 | 16 | 80 | 40 | 13 |
Abbreviations: AC Adenocarcinoma, HYP Hyperplastic polyp, SA Serrated adenoma, TA Tubular adenoma, TVA Tubulovillous adenoma, VA Villous adenoma