Table 2.

Predictions regarding the influence of SNPs in the promoters of erythroid genes (except the hemoglobin subunit genes) on TBP–TATA affinity, as performed by SNP-TATA-Z-tester [31]

Gene	Alleles: WT or mut	DNA sequence, TATA-like box; 5′-3′	Prognosis, −ln KD
ALAS1	WT rs564394089:A rs1046254329:A rs905035347:T	ctcccgctgtatattaaggcgccggc ctacAgctgtatattaaggcgccggc ctaccgctAtatattaaggcgccggc ctaccgctatatattaaggTgccggc	20.11 20.23 20.40 20.11
CA1	WT rs540950375:T rs991064314:T	ggaatgggcagcttatgtacaggggg ggaatgggcaTcttatgtacaggggg ggaatgggTagcttatgtacaggggg	19.81 19.70 19.82
CA1_2	WT rs557418569:G rs538698304:C	cttgggcatttttatagaaacttact cttgggcGtttttatagaaacttact cttgggcattttCatagaaacttact	20.22 20.16 19.61
HOXB2	WT rs762972656:T	aggactccagcgaaattacagggaat aggactccaTcgaaattacagggaat	17.98 17.92
EPOR	WT rs1006576690:T rs971717705:C rs567946217:A rs567946217:C	cgtagcagacaaaaatagatgacgtg cgtagcagacaaaTatagatgacgtg cgtagcagacaaaaaCagatgacgtg cgtagcagacaaaaataAatgacgtg cgtagcagacaaaaataCatgacgtg	18.24 19.39 18.11 19.33 18.51
GYPB	WT rs3967038:C rs3967038:A	gcctactagctgttatcttccaggcc gcctacCagctgttatcttccaggcc gcctacAagctgttatcttccaggcc	18.26 18.30 18.23
GYPC	WT rs970970552:A rs911469201:A rs989175270:G	cattggggagttttccctgcactcct cattAgggagttttccctgcactcct cattggggagttttccctAcactcct cattggggagttttccctgGactcct	16.97 17.83 17.13 17.27
EDRF1	WT rs946240545:G rs774081749:G rs895690311:G	tcgcgagatttaatggcgagtcacag tcgcgagGtttaatggcgagtcacag tcgcgagattGaatggcgagtcacag tcgcgagatttaatggcgGgtcacag	18.45 18.34 17.76 18.18

Notes: See “Notes” under Table 1. Genes: ALAS1 Aminolevulinate synthase 1; CA1 Carbonic anhydrase 1; CA1_2 Carbonic anhydrase promoter 2; HOXB2 Homeobox B2; EPOR Erythropoietin receptor; GYPB Glycophorin B; GYPC Glycophorin C; and EDRF1 Erythroid differentiation regulatory factor 1