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. 2020 Oct 21;18:404. doi: 10.1186/s12967-020-02567-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effect of hypoxia on monocyte migration. The red cross represents the mean end point of the trajectory of cells subjected to an oxygen gradient (a), under normoxic conditions (b) or subjected to a gradient of heat-inactivated hypoxia-inducing enzymes (c). Each graph shows one representative experiment, containing migration data of at least N = 20 cells. T1, time point < 5 min; T2, time point = 2.5 h; T3, time point = 5 h; H, hypoxia; HE, heat inactivated enzymes (GO and CAT)