Fig. 1.

DMF pretreatment of TNF stimulated HBMVEC modulates multiple inflammatory pathways. a Principal component analysis (PCA) of HBMVEC endothelial cell transcriptomes treated with TNF (10 ng/ml) for 6 h; DMF pretreatment (50 µM for 1 h) prior to TNF stimulation or untreated, segregate by experimental group. b Heat map of pathways differentially expressed between TNF versus DMF pretreated TNF stimulated HBMVEC. p < 0.005, FDR ≤ 0.01, FC > 2. Experiments done in triplicate. DMF dimethyl fumarate