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. 2020 Oct 21;20:516. doi: 10.1186/s12935-020-01556-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Knockdown and overexpression of ADAM17 in HCC cells affect MMP21 expression. a, b Expression of MMP21 in SMMC7721, Huh7 and MHCC97H cells. c, d The expression of MMP21 in SMMC7721 and Huh7 cells treated with ADAM17 siRNA. e, f The expression of MMP21 in SMMC7721 and Huh7 cells overexpressed ADAM17. (***P < 0.001, **P < 0.01, *P < 0.05)