Table 2.
Demographic and clinical characteristics of training and test sets focusing on within-indication subjects
| Training | Test | P-value | |||
|---|---|---|---|---|---|
| Characteristic | AEGIS (N = 189) |
Registry (N = 122) |
AEGIS (N = 246) |
Registry (N = 166) |
|
| Sex | 0.36 | ||||
| Female | 72 | 65 | 83 | 84 | |
| Male | 117 | 57 | 163 | 82 | |
| Median age (IQR) | 62 (54–70) | 64 (57–71) | 62 (54–70) | 65 (58–71) | 0.45 |
| Race | 0.59 | ||||
| White | 141 | 106 | 192 | 132 | |
| Black | 34 | 14 | 42 | 29 | |
| Other | 11 | 2 | 12 | 4 | |
| Unknown | 3 | 0 | 0 | 1 | |
| Smoking status | 0.45 | ||||
| Current | 79 | 48 | 107 | 73 | |
| Former | 110 | 74 | 139 | 93 | |
| Median cumulative tobacco use (IQR) – pack-year | 40 (18–57) | 35 (20–50) | 35 (20–56) | 35 (20–56) | 0.82 |
| Lesion size | < 0.001 | ||||
| Infiltrate | 0 | 0 | 25 | 0 | |
| < 2 cm | 42 | 61 | 88 | 80 | |
| 2 to 3 cm | 30 | 29 | 48 | 29 | |
| > 3 cm | 41 | 26 | 75 | 44 | |
| Unknown | 60 | 6 | 10 | 13 | |
| Lesion location | 0.47 | ||||
| Central | 50 | 9 | 72 | 10 | |
| Peripheral | 78 | 107 | 108 | 144 | |
| Central and peripheral | 46 | 0 | 53 | 0 | |
| Unknown | 15 | 6 | 13 | 12 | |
| Lung-cancer histologic type | 0.025 | ||||
| Small-cell | 8 | 3 | 8 | 1 | |
| Non-small-cell | 69 | 48 | 100 | 43 | 0.18 |
| Adenocarcinoma | 30 | 25 | 58 | 25 | |
| Squamous | 28 | 12 | 26 | 10 | |
| Large-cell | 6 | 1 | 4 | 0 | |
| Non-small-cell not otherwise specified | 5 | 10 | 12 | 8 | |
| Other | 0 | 2 | 0 | 2 | |
| Unknown | 21 | 3 | 3 | 6 | |
| Diagnosis of a benign condition | < 0.001 | ||||
| Fibrosis | 1 | 0 | 1 | 0 | |
| Granuloma | 15 | 6 | 26 | 10 | |
| Infection | 30 | 15 | 36 | 15 | |
| Inflammation | 4 | 2 | 1 | 2 | |
| Multiple | 6 | 0 | 8 | 0 | |
| Other | 17 | 4 | 25 | 2 | |
| Resolution of Stability | 18 | 39 | 38 | 40 | |
| Clinically benign | 0 | 0 | 0 | 45 | |