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. 2020 Oct 22;18:151. doi: 10.1186/s12951-020-00710-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Bioinformatic analysis of global mRNA expression in Sr-exosomes of twenty osteosarcoma patients and six healthy donors. a Clinical characteristics of OS patients, which received Sr-exosome RNA sequence; b Volcano plots of differently expressed genes in Sr-exosomes of six healthy donors and twenty OS patients; c GO analysis demonstrating Sr-exosomes of OS patients involving in the process of immune function, which was indicated by arrow; d KEGG pathways analysis revealing the enrichment in Sr-exosomal mRNA between OS patients and healthy donors; e Hierarchical clustered heatmap of differently expressed genes in Sr-exosomes of six healthy donors and twenty OS patients