Table 3.
Factors Associated With Pneumococcal VCR (CPRD; 2011–2015)
| Univariate logistic regression | Full Cox regression | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age | ||||
| 18–49 | Reference group | Reference group | ||
| 50–64 | 1.14 (1.10, 1.19) | P < 0.0001 | 0.96 (0.93, 1.00) | P = 0.051 |
| Gender | ||||
| Male | Reference group | Reference group | ||
| Female | 0.96 (0.93, 1.00) | P = 0.033 | 0.91 (0.88, 0.95) | P < 0.0001 |
| Region | ||||
| North East | Reference group | |||
| North West | 1.64 (1.37, 1.97) | P < 0.0001 | 1.52 (1.27, 1.82) | P < 0.0001 |
| Yorkshire and the Humber | 1.96 (1.59, 2.42) | P < 0.0001 | 1.98 (1.60, 2.44) | P < 0.0001 |
| East Midlands | 1.60 (1.20, 2.13) | P = 0.001 | 1.49 (1.12, 1.99) | P = 0.006 |
| West Midlands | 1.75 (1.46, 2.10) | P < 0.0001 | 1.66 (1.39, 2.00) | P < 0.0001 |
| East of England | 1.60 (1.32, 1.93) | P < 0.0001 | 1.57 (1.30, 1.90) | P < 0.0001 |
| South West | 1.46 (1.21, 1.75) | P < 0.0001 | 1.45 (1.21, 1.75) | P < 0.0001 |
| South Central | 1.51 (1.25, 1.81) | P < 0.0001 | 1.48 (1.23, 1.77) | P < 0.0001 |
| London | 1.37 (1.14, 1.65) | P = 0.0001 | 1.30 (1.08, 1.56) | P = 0.005 |
| South East Coast | 1.36 (1.13, 1.64) | P = 0.001 | 1.34 (1.12, 1.61) | P = 0.002 |
| Northern Ireland | 1.57 (1.30, 1.90) | P < 0.0001 | 1.38 (1.14, 1.68) | P = 0.001 |
| Scotland | 1.98 (1.65, 2.37) | P < 0.0001 | 1.92 (1.61, 2.30) | P < 0.0001 |
| Wales | 0.96 (0.80, 1.16) | P = 0.677 | 1.02 (0.85, 1.22) | P = 0.870 |
| Individuals with only one underlying medical condition | ||||
| Immunosuppression | Reference group | Reference group | ||
| Cerebrospinal fluid leaks | 0.52 (0.31, 0.86) | P = 0.01 | 0.77 (0.47, 1.29) | P = 0.322 |
| Chronic heart disease | 0.91 (0.85, 0.97) | P = 0.006 | 0.71 (0.66, 0.76) | P < 0.0001 |
| Chronic kidney disease | 0.63 (0.54, 0.74) | P < 0.0001 | 0.55 (0.46, 0.64) | P < 0.0001 |
| Chronic liver disease | 0.53 (0.46, 0.62) | P < 0.0001 | 0.55 (0.47, 0.64) | P < 0.0001 |
| Chronic respiratory disease | 1.05 (0.98, 1.11) | P = 0.181 | 0.86 (0.80, 0.91) | P < 0.0001 |
| Diabetes mellitus | 1.09 (1.03, 1.16) | P = 0.004 | 0.82 (0.77, 0.88) | P < 0.0001 |
| Influenza vaccine use in the first year of follow-up | ||||
| No | Reference group | Reference group | ||
| Yes | 8.68 (8.11, 9.29) | P < 0.0001 | 8.78 (8.19, 9.40) | P < 0.0001 |
CI Confidence interval, CPRD Clinical Practice Research Datalink, HR Hazard ratio, VCR Vaccination coverage rate