Fig. 3.

The expression level of ERdj8 alters the size of the autophagosomes. a Autophagosomes can capture both small and large substrates when ERdj8 expression is at the endogenous level. b ERdj8 overexpression induces the expansion of autophagosome membrane and both small and large substrates are degraded by autophagy. c Knockdown of ERdj8 induces the small autophagosomes to capture small substrates, whereas the degradation of large substrates is disabled