Table 2.
The pooled results and evidence quality in efficacy outcomes
| Outcome | RCT | NRCT | Cohort study | |||
|---|---|---|---|---|---|---|
| Estimate (95% CI) | Evidence quality a | Estimate (95% CI) | Evidence quality a | Estimate (95% CI) | Evidence quality a | |
| Short-term outcome | ||||||
| ORR | RR 1.34 (0.91–1.98) | Moderate | RR 1.14 (0.85–1.53) | Low | RR 1.39 (0.81–2.39) | Very low |
| DCR | RR 1.11 (0.94–1.30) | Moderate | RR 1.09 (0.91–1.30) | Low | RR 1.07 (0.94–1.21) | Very low |
| Survival outcome | ||||||
| OS | – | – | – | – | HR 0.68 (0.42–0.94) * | Very low |
| PFS | – | – | – | – | HR 0.71 (0.51–0.90) * | Very low |
a The evidence quality was evaluated by GRADE. Moderate: we are moderately confident in the effect estimate (the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different); Low: our confidence in the effect estimate is limited (the true effect may be substantially different from the estimate of the effect); Very low: we have very little confidence in the effect estimate (the true effect is likely to be substantially different from the estimate of effect)
* A statistically significant difference exists (P < 0.05)