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. 2020 Oct 8;10:579940. doi: 10.3389/fonc.2020.579940

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Copyright © 2020 Arman and Möröy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MYC regulated lncRNAs. Overview of MYC regulated lncRNAs along with their known biological function in different hematological malignancies. The regulation of the expression of specific lncRNAs by MYC is context dependent and is specific for the hematological malignancy. For example, MYC regulates DANCR in AML, which affects leukemic stem cells, but in BCL the regulation of DANCR by MYC targets the function of the negative cell cycle regulator p21 (CDKN1A). Similarly, MYC can regulate the expression of NEAT1 in CML or DLBCL, but this affects Imatinib response or the miR-34b-5p-GL1 axis, respectively. In contrast, MYC can regulate SNHG12 in BCL or in NKTCL, which in both cases can alter drug resistance. Abbreviations: BL, Burkitt lymphoma; BCL, B-cell lymphoma; AML, Acute myeloid leukemia; DLBCL, Diffuse large B cell lymphoma; CML, Chronic myeloid leukemia; and NKTCL, Natural Killer/T-cell lymphoma.