Fig. 2.

Comparison of three distinct patterns of biologically-aggressive meningiomas. The first and most common subclass (50%) contained NF2-mutant tumors, was associated with male sex and harbored additional alterations in CDKN2A/B, ARID1A, PTEN, and KDM6A. A second group featured TERTp or TP53 mutations and were either NF2-mutant or wild-type and with no association with either sex. The remaining group which accounted for 40% of the cases, generally lacked NF2 mutations and harbored alterations in BAP1/PBRM1, with a further subgroup containing AKT1, PIK3CA and SMO mutant meningiomas and a third with a heterogeneous spectrum of low frequency and non-recurrent alterations