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. 2020 Jun 3;1(1):100019. doi: 10.1016/j.xpro.2020.100019

Figure 10.

Figure 10

Examples of 7-Day Old Human Colon Organoid Cultures (Bright Field, 4 x Magnification)

(A) Typical pre-swollen stem cell phenotype of a high quality, proliferated wild type (non-CF) human colon organoid culture.

(B) Non-swollen stem cell phenotype of a high quality, proliferated CF colon organoid culture.

(C) Example of a bad quality CF colon organoid culture with thick-walled, differentiated structures with decreased stem cell phenotype which is often due to low activity of Wnt-3A in WCM.