Table 2.
Main studies reporting anakinra administration in pediatric idiopathic recurrent pericarditis.
| Type of study | Patients (n) | Dose | Response | Adverse events | Median follow up (months) | |
|---|---|---|---|---|---|---|
| Picco et al.25 | Case series | 3 | 1 mg/kg/day | Remission Relapse after discontinuation | NA | 4.2 (range 4–6) |
| Scardapane et al.29 | Case report | 1 | 100 mg/day, Month 10 at alternate days |
Remission | None | 12 |
| Camacho-Lovillo et al.30 | Case report | 1 | 2 mg/kg/day | Remission, relapse after discontinuation | NA | 36 |
| Finetti et al.31 | Retrospective | 12 | Starting dose of 1.3 mg/ kg/day (range 1–2 mg/kg/day) |
Remission, 5 patients off therapy | Local injection-site reaction | 34.5 (range 14–57) |
| Imazio et al.23 | Retrospective | 12 | 1 mg/kg/day | Remission | NA | NA |
| Brucato et al.32 | Randomized controlled trial | 1 | 2 mg/kg/day | Remission | NA | 12 |
NA, not available.