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. 2020 Oct 16;13:1756284820942616. doi: 10.1177/1756284820942616

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Apical junctional complex: TJ consisting of transmembrane proteins (claudin, occludin, JAM) and cytoplasmic molecules (ZO-1, ZO-2). Adherens junction sits below the TJ and also consists of transmembrane (VE-cadherin) and cytoplasmic (catenin) component proteins. The cytoplasmic molecules connect to F-actin, which contracts to open the paracellular space.

JAM, junctional adhesional molecule; TJ, tight junction; VE-cadherin, vascular endothelial cadherin; ZO-1, ZO-2, zonula-occludens 1 and 2.