Table 2.
Medians and ranges of the 14 immunological parameters included in the exploratory factor analysis, with the addition of VNA titers at D7.
| Immune parameters | Day | Indicator | Group A | Group B | Group C | Group D |
|---|---|---|---|---|---|---|
| VNA titers(IU/ml) | D7 | Median | 0.16 | 0.72 | 0.52 | 0.40 |
| Range [minimum; maximum] | [0.06; 0.66] | [0.06; 2.62] | [0.29; 3.46] | [0.17; 1.15] | ||
| VNA titers(IU/ml) | D28 | Median | 7.92 | 12.11 | 7.50 | 5.29 |
| Range [minimum; maximum] | [3.46; 10.45] | [6.01; 41.59] | [4.56; 72.27] | [4.56; 13.77] | ||
| Total IgGconcentrations(Log10 OD50) | D28 | Median | 2.44 | 3.18 | 2.87 | 2.59 |
| Range [minimum; maximum] | [2.22; 2.86] | [2.53; 3.61] | [2.49; 3.82] | [2.25; 3.17] | ||
| IgG1concentrations(Log10 OD50) | D28 | Median | 2.33 | 3.02 | 2.62 | 2.46 |
| Range [minimum; maximum] | [2.14; 2.81] | [2.52; 3.52] | [2.38; 3.66] | [2.12; 3.11] | ||
| Number of IgG-secreting cells/250E3 PBMCs | D7 | Median | 0.00 | 13.00 | 7.00 | 5.00 |
| Range [minimum; maximum] | [0.00; 9.00] | [1.00; 26.00] | [0.00; 32.00] | [5.00; 10.00] | ||
| Number of IFN-γ-secreting cells/250E3 PBMCs | D14 | Median | 6.50 | 2.00 | 4.50 | 3.25 |
| Range [minimum; maximum] | [1.50; 11.00] | [0.00; 8.50] | [1.00; 8.50] | [0.50; 23.00] | ||
| IFN-γ release(pg/ml) | D14 | Median | 37907.68 | 34282.45 | 42838.48 | 28871.47 |
| Range [minimum; maximum] | [6913.51; 41954.30] | [18670.08; 41089.41] | [27780.47; 50632.98] | [17174.51; 44256.46] | ||
| IL-10 release(pg/ml) | D14 | Median | 3789.61 | 3945.09 | 5015.65 | 2585.72 |
| Range [minimum; maximum] | [1310.46; 4912.06] | [2277.76; 9633.83] | [2019.95; 7843.86] | [1717.10; 8613.74] | ||
| IL-2 release(pg/ml) | D14 | Median | 443.54 | 476.93 | 400.94 | 380.52 |
| Range [minimum; maximum] | [397.18; 475.45] | [295.41; 901.93] | [355.40; 695.56] | [276.58; 852.70] | ||
| IL-6 release(pg/ml) | D14 | Median | 798.83 | 947.07 | 1062.92 | 708.50 |
| Range [minimum; maximum] | [408.38; 920.59] | [471.08; 1743.06] | [571.45; 2616.34] | [451.71; 1640.59] | ||
| TNF-α release(pg/ml) | D14 | Median | 872.02 | 2015.12 | 2791.53 | 855.43 |
| Range [minimum; maximum] | [129.97; 1528.00] | [617.60; 7465.44] | [682.17; 4419.53] | [255.77; 2314.72] | ||
| IL-1β release(pg/ml) | D14 | Median | 55.94 | 66.30 | 60.80 | 50.90 |
| Range [minimum; maximum] | [3.52; 90.99] | [3.52; 259.97] | [12.52; 174.09] | [21.86; 80.86] | ||
| SCF release(pg/ml) | D14 | Median | 536.66 | 864.23 | 916.98 | 493.60 |
| Range [minimum; maximum] | [157.35; 775.92] | [370.80; 1326.26] | [452.33; 1767.22] | [270.69; 1439.44] | ||
| β-NGF release(pg/ml) | D14 | Median | 194.93 | 209.20 | 208.48 | 128.82 |
| Range [minimum; maximum] | [55.40; 282.51] | [114.01; 1548.47] | [103.93; 637.21] | [64.58; 260.67] | ||
| IL12p40 release(pg/ml) | D14 | Median | 1425.25 | 1577.44 | 1774.76 | 1427.07 |
| Range [minimum; maximum] | [1154.03; 1735.20] | [699.75; 1835.76] | [1157.24; 2342.68] | [998.80; 2107.06] |