Table 2.

Rab GTPases in endocytic pathways.

Endosomal pathways	Rab proteins	Molecular functions	Cellular functions in dendrites	Main effectors	Main cargoes	References
Endocytosis	Rab5	PM to EE vesicle trafficking, vesicle budding, vesicle motility, vesicle uncoating, and vesicle tethering.	Dendritic branching, development, thinning, and pruning	VPS34, EEA1, Rabaptin-5, Rabex-5	TfR, EGFR, B2AR, TrkB	Stenmark et al. (1995), Horiuchi et al. (1997), McLauchlan et al. (1998), Rubino et al. (2000), Leonard et al. (2008), Satoh et al. (2008), Semerdjieva et al. (2008), von Zastrow and Williams (2012), Kanamori et al. (2015), Zhang et al. (2014), Wang et al. (2017), and Moya-Alvarado et al. (2018)
Exocytosis (Rapid recycling)	Rab35	EE to PM vesicle trafficking.	Neurite outgrowth	EPI64C, ACAP2, MICAL-L1	TfR, TCR	Kouranti et al. (2006), Patino-Lopez et al. (2008), Kobayashi and Fukuda (2013), and Kobayashi et al. (2014)
	Rab4	EE to PM vesicle trafficking.	Dendritic branching and development; Spine formation	Arl1, BIG1, BIG2, GRASP-1, NBEA	TfR, GPCRs, AMPA receptor, NMDA receptor	Seachrist et al. (2000), Seachrist and Ferguson (2003), Odley et al. (2004), Zheng et al. (2008), Yudowski et al. (2009), Hoogenraad et al. (2010), Esseltine et al. (2011), D’Souza et al. (2014), and Gromova et al. (2018)
Exocytosis (Slow recycling)	Rab11	Vesicle trafficking and motility from EE to RE or from RE to PM; RE biogenesis.	Dendritic branching and pruning; Spine growth	Rab11-FIPs, MyoVb, Dynein, Sec15	AMPA receptor, TfR, EGFR, TLR4, β1 integrin, N-cadherin, E-cadherin, TrkB	Ullrich et al. (1996), Sönnichsen et al. (2000), Park et al. (2004), Zhang et al. (2004), Park et al. (2006), Wang et al. (2008), Horgan et al. (2010), Kelly et al. (2012), Lazo et al. (2013), Kramer et al. (2019), and Lin et al. (2020)
	Rab22	EE to RE vesicle trafficking; RE biogenesis.	N/A	N/A	TfR, CD1a, MHC class1, TrkA	Weigert et al. (2004), Magadan et al. (2006), Barral et al. (2008) and Wang et al. (2011)
	Rab25	EE to RE vesicle trafficking; Vesicle sorting between RE and LE.	N/A	N/A	IgA, TfR, β1 integrin	Casanova et al. (1999), Wang et al. (2000), Caswell et al. (2007), Dozynkiewicz et al. (2012), and Jeong et al. (2019)
	Rab10	EE to RE vesicle trafficking; Vesicle motility; RE biogenesis.	Dendritic development and branch patterning	Kif13A/B	CD147, TfR	Chen et al. (2006), Taylor et al. (2015), Zou et al. (2015), and Etoh and Fukuda (2019)
	Rab8	RE to PM vesicle trafficking.	Dendritic spine growth	N/A	AMPA receptor, TfR	Hattula et al. (2006) and Brown et al. (2007)