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. 2020 Oct 7;11:581758. doi: 10.3389/fimmu.2020.581758

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Copyright © 2020 O'Riordan, Purvis, Collotta, Krieg, Wissuwa, Sheikh, Ferreira Alves, Mohammad, Callender, Coldewey, Collino, Greaves and Thiemermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of significant restored metabolites in the groups XID CLP, WT CLP + Ibrutinib, and XID CLP + Ibrutinib. (A) Hierarchical clustered z score heatmaps showed significantly changed analytes and (B) log2-fold change heatmaps showed their significant log2-fold changes for selected groupwise comparisons. The heatmap shows analytes which, compared to the WT CLP group (n = 10), restored in all three groups [Xid-CLP (n = 10), WT-CLP + ibrutinib (n = 8), and Xid-CLP + ibrutinib (n = 6)] to the level of the two sham groups [WT Sham (n = 5), Xid Sham (n = 5)]. Each column in a z score heatmap represented the mean value of all animals in a group, each column in a log2-fold change heatmap represented a groupwise comparison and each row defined an analyte. Analytes were hierarchically clustered using Ward's minimum variance method (76) and an euclidian distance between log2-fold changes. Dendrograms provide information about distances between clusters. AA, arachidonic acid; AEA, arachidonoylethanolamide; DHA, docosahexaenoic acid; DOPA, dihydroxyphenylalanine; EPA, eicosapentaenoic acid; LPE, lysophosphatidylethanolamine; LPG, lysophosphatidylglycerol; LPS, lysophosphatidylserine; lyso-PAF, lyso-platelet activating factor; OEA, oleoylethanolamine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosphatidylserine; TDCA, taurodeoxycholic acid.