Skip to main content
. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Gastroenterology. 2019 Aug 13;158(4):1072–1082.e7. doi: 10.1053/j.gastro.2019.08.016

Fig. 2. Focal inflammation and stress responses occurred in mice expressing mutant R122H trypsinogen.

Fig. 2.

A. Despite no obvious spontaneous pancreatitis, small focal areas of immune cell infiltrations were more often found in the pancreas of mice expressing mutant R122H trypsinogen than in wild-type trypsinogen (PRSS1) and control mice (BAC). Representative immunohistochemical images for CD45 positive cells in control mice (BAC) and R122H and PRSS1 mice. B. Quantification under light microscope of CD45 positive cells for control (BAC), R122H and PRSS1 mice. C-E. Relative mRNA expression of nuclear factor (erythroid-derived 2)-like 2 (NRF2) (C), heat shock protein 70 (HSP70) (D) and CTRC (E) in R122H, PRSS1 and control mice (BAC) was measured by real-time RT-PCR. (*, p<0.05; **, p<0.01; ns, p>0.05).