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A working model for DUSP26-mediated p53 dephosphorylation and inactivation. Genotoxic stress such as doxorubicin and VP-16 induces p53 expression and phosphorylation in neuroblastoma cells. DUSP26 binds to and dephosphorylates p53 at Ser20 and Ser37 residues to inhibit p53 tumor suppressor function and promotes the resistance of tumor cells to doxorubicin-induced cell death.
