TABLE.

Characteristics of Brain Bank Participants and Those Available for Immunostaining

	All Potential Subjects	Paraformaldehyde-Fixed and All Brain Regions	Prussian Blue	Prussian Blue
			Top Quartile	Bottom Quartile
	n = 113	n = 76	n = 19	n = 19
Age, years
Mean ± SE	91 ± 1.2	90 ± 1.4	93 ± 2.6	85 ± 3.5
Range	46–110	58–110	68–110	58–101
MMSE
Mean ± SE	17.4 ± 0.9	16.3 ± 1.1	13.8 ± 2.3	16.3± 2.2
Range	0–30	0–30	0–30	0–28
Number missing data	9	7	1	4
Male	40 (35%)	29 (38%)	9 (47%)	7 (37%)
Smoker	47 (44%)	30 (43%)	9 (50%)	5 (29%)
Number missing data	7	6	1	2
Medical History
Hypertension	77 (72%)	48 (69%)	13 (72%)	12 (67%)
Number missing data	6	5	1	1
Diabetes	10 (9.3%)	7 (9.9%)	2 (11%)	2 (11%)
Number missing data	6	5	1	1
Stroke	18 (17%)	9 (13%)	4 (22%)	1 (6%)
Number missing data	7	7	1	1
TIA	24 (23%)	12 (18%)	4 (22%)	1 (6%)
Number missing data	10	8	1	1
APOE genotype
Number missing data	24	17	3	7
23	10 (11%)	6 (10%)	3 (19%)	1 (8%)
24	2 (2%)	2 (3%)	2 (13%)
33	53 (60%)	37 (63%)	5 (31%)	7 (58%)
34	20 (22%)	12 (20%)	5 (31%)	4 (33%)
44	4 (4%)	2 (3%)	1 (6%)
Diagnosis
Normal	54 (48%)	31 (41%)	8 (42%)	6 (32%)
Alzheimer’s disease	32 (28%)	24 (32%)	3 (16%)	10 (53%)
Alzheimer’s disease with other pathology	19 (17%)	16 (21%)	5 (26%)	2 (11%)
With Lewy body	2	2		1
With Lewy body, hippocampal sclerosis	1	1
With vascular dementia	2	2	1	1
With vascular dementia (amyloid angiography)	3	3	2
With vascular dementia (amyloid angiography), hippocampal sclerosis	2
With hippocampal sclerosis	8	7	2
With other	1	1
Vascular dementia	2 (2%)
Hippocampal sclerosis	3 (3%)	2 (3%)	2 (11%)
Parkinson’s disease	1 (1%)	1 (1%)
Other	2 (2%)	2 (3%)	1 (5%)	1 (5%)
Prussian blue
Mean ± SE		4384 ± 750	12 839 ± 1930	192 ± 47*
Range		0–31 690	5435–31 690	0–663

^*p < 0.05 for difference between top and bottom quartiles of Prussian blue load.