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. Author manuscript; available in PMC: 2020 Oct 22.
Published in final edited form as: Oncogene. 2012 Feb 27;32(3):296–306. doi: 10.1038/onc.2012.58

Figure 9.

Figure 9.

MiR-1 regulates EMT and mesenchymal commitment via Slug and acts independently as a tumor suppressor by regulating additional targets. (a) qPCR analysis of mesenchymal differentiation markers expression in precursor miR-1 and miR-200b AC3E+ cells or precursor miRs AC3E+ cells reconstituted with Slug expression vector (miRs/Slug). Data represent means±s.e.m., n=3. (b) Predicted miR-1 target genes. Data represent numbers of miR-1 binding sites and miRSVR score. (c) qPCR analysis of miR-1 target genes expression in Slug-depleted (SKD) AC3E+ cells with or without anti-miR-1 expression or precursor miR-1-expressing AC3E+ cells with or without Slug cDNA overexpression. Data represent means±s.e.m., n=3.