Table 1.

Single patient-oriented studies leveraging intensive monitoring to identify either health status changes or the effects of an intervention.

Authors	Reference	Study Elements	Comments
David et al. (2014)[93]	PMID: 25146375	Diet and microbiome	2 individuals fecal microbiome tracked for a year
Chen et al. (2012)[94]	PMID: 22424236	Multiomics profiling	Individual tracked over a year (the ‘Snyderome’ study)
Magnuson et al. (2016)[95]	PMID: 28781744	Sleep treatment study	Patient with multiple treatments for compromised sleep
Zeevi et al. (2015)[96]	PMID: 26590418	Glycemic responses to diet	800 people studied to develop personalized diets
Smarr et al. (2017)[97]	PMID: 29582916	Colonoscopy effects	Gut microbiome changes post colonoscopy
Tremmell et al. (2016)[98]	PMID: 27721479	NAD dose response	Single individual dosing study + study of others
Forsdyke (2015)[99]	PMID: 26055103	Response to antihypertensives	Decade of seasonal variation in response to Losartan
O’Rawe et al. (2013)[100]	PMID: 24109560	Deep brain stimulation (DBS)	2 year study of a man with OCD treated with DBS
Li et al. (2016)[101]	PMID: 27140603	Parkinson cell replacement	Single individual traced for 24 years post cell transplant
Bloss et a. (2016)[102]	PMID: 25790160	Idiopathic neurologic disease	Severely disabled individual treated for sleep tremors
Piening et al. (2018)[103]	PMID: 29361466	Multiomics weight loss study	23 individuals observed over time
Zalusky et al. (1961)[104]	PMID: 14009735	Folate supplementation	Study of an individual with severe dietary constraints
V. Herbert (1962)[105]	PMID: 13953904	Folate supplementation	Study on the researcher himself; dietary restriction
P. H. Golding (2014)[106]	PMID: 25332850	Folate supplementation	Study on the researcher himself; dietary restriction