Table 5A.

Cox Proportional Hazards Regression for Death based on T1 Epoch (1st 72 h Post-Injury) Biomarkers

	Model 1£		Model 2§		Model 3¥		Model 4€
	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
ln(E2) ln(TNFα) Harrell Concordance Statistic	1.84 (1.31, 2.59) 1.56 (1.067, 2.27) 0.707	< 0.001 0.022	1.74 (1.22, 2.50) 1.55 (1.033, 2.31) 0.790	0.002 0.034	1.79 (1.15, 2.81) 1.44 (1.00, 2.08) 0.835	0.011 0.051	1.81 (1.14, 2.87) 1.47 (0.99, 2.19) 0.834	0.012 0.056

CI, confidence interval; E2, estradiol; TNFα, tumor necrosis factor alpha.

£: Model 1: Unadjusted.

§: Model 2: Adjusted for age only.

¥: Model 3: Adjusted for age and clinical variables (Glasgow Coma Scale, non-head Injury Severity Score, and computed tomography abnormalities: contusion, subdural hematoma, diffuse axonal injury).

€: Model 4: Adjusted for age, clinical variables, and rs2470152 genotype.