Table 5B.

Cox Proportional Hazards Regression for Death Based on T2 Epoch (2nd 72 h Post-Injury) Biomarkers

	Model 1£		Model 2§		Model 3¥		Model 4€
	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
ln(E2) ln(TNFα) Harrell's Concordance Statistic	1.36 (0.91, 2.02) 1.69 (1.03, 2.79) 0.696	0.133 0.039	1.24 (0.84, 1.83) 1.71 (1.05, 2.76) 0.756	0.287 0.030	1.10 (0.70, 1.74) 2.14 (1.22, 3.75) 0.804	0.680 0.008	0.91 (0.56, 1.47) 2.47 (1.35, 4.53) 0.819	0.691 0.003

CI, confidence interval; E2, estradiol; TNFα, tumor necrosis factor alpha.

£: Model 1: Unadjusted.

§: Model 2: Adjusted for age only.

¥: Model 3: Adjusted for age and clinical variables (Glasgow Coma Scale, non-head Injury Severity Score, and computed tomography abnormalities: contusion, subdural hematoma, diffuse axonal injury).

€: Model 4: Adjusted for age, clinical variables, and rs2470152 genotype.