. 2020 Oct 7;37(20):2198–2210. doi: 10.1089/neu.2019.6577

Table 6B.

Mediation Model of the Relationship between T1 and T2 Tumor Necrosos Factor Alpha and Six-Month Mortality

Mediators (analyzed separately)	Association between T1 TNFα and mediator	*T1 TNFα*			Association between T2 TNFα and mediator	*T2 TNFα*
Mediators (analyzed separately)	Association between T1 TNFα and mediator	Total effect	Direct effect	Mediation %	Association between T2 TNFα and mediator	Total effect	Direct effect	Mediation %
	OR (95% CI)	OR (95% CI)	OR (95% CI)		OR (95% CI)	OR (95% CI)	OR (95% CI)
1. Cardiovascular dysfunction	1.29 (0.80, 2.07)	2.19 (1.19, 4.03)^*	2.22 (1.17, 4.24)^*	††	2.36 (1.33, 4.19)^*	2.89 (1.47, 5.67)^*	2.47 (1.24, 4.92)^*	20.01^¥
2. Hematology dysfunction	1.49 (0.86, 2.58)	2.64 (1.28, 5.46)^*	2.56 (1.26, 5.34)^*	3.81^¥	1.94 (1.07, 3.53)^*	3.77 (1.67, 8.50)^*	3.63 (1.58, 8.32)^*	3.41^¥
3. Renal dysfunction	4.78 (2.00, 11.44)^*	3.20 (1.46, 6.98)^*	2.37 (1.00, 5.59)^*	30.13^¥	4.28 (1.81, 10.14)^*	3.76 (1.64, 8.59)^*	2.68 (1.08, 6.64)^*	29.70^¥
4. Hepatic dysfunction	1.11 (0.47, 2.60)	2.11 (1.06, 4.19)^*	2.13 (1.04, 4.35)	††	3.08 (1.30, 7.30)^*	3.82 (1.69, 8.65)^*	3.44 (1.47, 8.06)^*	10.34^¥
5. Respiratory dysfunction	1.02 (0.53, 1.98)	2.36 (1.24, 4.50)^*	2.36 (1.24, 4.50)^*	††	1.23 (0.54, 2.80)	3.81 (1.77, 8.22)^*	3.82 (1.77, 8.26)^*	††
	IRR (95% CI)	OR (95% CI)	OR (95% CI)	Mediation %	IRR (95% CI)	OR (95% CI)	OR (95% CI)	Mediation %
6. Total count of system dysfunction	1.21 (0.97, 1.49)	3.34 (1.41, 7.90)^*	3.10 (1.23, 7.78)^*	13.02^¥	1.32 (1.07, 1.63)^*	6.34 (2.13, 18.89)^*	5.31 (1.63, 17.30)^*	15.14^¥

TNFα, tumor necrosis factor alpha; OR, odds ratio; CI, confidence interval; IRR, incidence rate ratio.

^{^*}

Indicates p < 0.05; All paths adjusted for age and sex.

^††

: Total effect not significant and/or total effect ≤ direct effect, mediation % not calculated.

¥: Indicates a partial mediator.

€: Indicates a full mediator.