Figure 6.

Acidified Exos^Lamp2b-HuR effectively alleviate CCL4-induced liver injury.

(a) Schematic representation of the experimental procedure. (b-d) Endogenous expression of miR-155 (b), Tnfα (c), Mcp1 (d), and Col1a1 (e) in livers from mice receiving indicated treatments. Livers were harvested 48 h after the last exosome injection. U6 or β-actin served as internal control, respectively. Data are expressed as mean±SEM of three different experiments. *, p$<$ 0.05. (f) Sirius red staining of the livers from mice receiving indicated treatments. Mice were treated with control or CCL₄ for 4 weeks. About 200 µg indicated exosomes (at protein level) were injected 24 h after each CCL₄ treatment. Livers were harvested 48 h after the last exosome injection for Sirius red staining. n = 5 mice in each group. (g) Quantification data of panel f.